EVIDENCE & SAFETY · ADULTS 21+
Kratom: what the evidence does—and does not—show
Clear information should acknowledge both uncertainty and reported harm. Personal experiences, surveys, laboratory findings and clinical reports answer different questions. None should be used alone to promise safety or a medical benefit.
Reports are not all the same as proof of cause
Some serious adverse-event reports involve other substances, incomplete medical histories or products with uncertain composition. Those limitations can make causation difficult to determine. They do not prove that kratom could not have contributed.
FDA reports that deaths associated with kratom use have usually involved other drugs and that kratom’s contribution in those cases is unclear. We do not claim that there have been “zero deaths,” that unadulterated kratom cannot cause serious harm, or that every adverse event comes from contamination.
Natural does not mean risk-free
Plain leaf products and extracts can differ in alkaloid content. Contamination and adulteration are additional concerns, but product purity does not remove risks related to kratom itself, interactions or individual health conditions. Results in animals cannot establish safety in people.
Dependence deserves attention
Regular use can lead to tolerance or dependence in some people. Withdrawal may occur when use is stopped, and its severity varies. A brief break schedule has not been established to prevent dependence. If you are increasing use, finding it difficult to stop, or experiencing withdrawal, seek advice from a qualified healthcare professional rather than relying on a website “reset” plan.
Important safety information
Some people who use kratom regularly develop dependence and experience withdrawal when stopping. Nausea, constipation, dizziness, and drowsiness have been reported. Rare but serious events, including seizures and liver injury, have also been reported in people using kratom. Some reports involve other substances, varying product composition, or incomplete information, which can make the cause difficult to determine. These limitations do not establish that kratom is risk-free or rule out its contribution to harm.
For adults 21+ only. Do not use during pregnancy or breastfeeding. Do not combine kratom with alcohol, opioids or other drugs. Discuss medications and health conditions with a qualified healthcare professional before use. Do not drive or operate machinery after use. Keep products out of reach of children.
Stop use and seek medical advice if you experience an adverse reaction. Call 911 for trouble breathing, a seizure, collapse or loss of consciousness. Seek prompt medical care for yellowing of the skin or eyes, dark urine, or persistent vomiting.
Medical claims and informed decisions
Kratom is not an FDA-approved treatment. Do not replace prescribed treatment or attempt to manage opioid withdrawal with kratom without professional medical care. Ask about medication interactions and your personal health circumstances before use.
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Read the evidence
NIH: kratom research and safety · FDA information on kratom
Information reviewed October 3, 2026. Research continues to develop. This page provides general information and does not replace professional medical advice. Our products are not intended to diagnose, treat, cure or prevent any disease.